Exposure to non-steroidal anti-inflammatory drugs during pregnancy and risk of miscarriage

In general, there is a very low frequency of serious adverse reactions to the rabies PEP regimen. Local pain, headache and low-grade fever may follow administration of HRIG. Pain, erythema, swelling, itching, and other mild local reactions are reported among 11-90% of vaccines. Rabies PEP should not be interrupted or discontinued because of local or mild systemic adverse reactions to rabies vaccine. Non-steroidal anti-inflammatory drugs and antipyretic agents, such as ibuprofen or acetaminophen, may be used to control mild adverse reactions.

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To minimize the potential risk for an adverse GI event in patients treated with an NSAID, the lowest effective dose should be used for the shortest possible duration. Patients and physicians should remain alert for signs and symptoms of GI ulceration and bleeding during NSAID therapy and promptly initiate additional evaluation and treatment if a serious GI adverse event is suspected. This should include discontinuation of the NSAID until a serious GI adverse event is ruled out. For high risk patients, alternate therapies that do not involve NSAIDs should be considered.

BRCA1 and BRCA2 mutations confer a high risk of breast cancer in carriers (high-penetrance). Women with a BRCA1 or BRCA2 mutation have a 45-65% chance of developing breast cancer by age 70.[ 7 ] BRCA1/2 mutation-carriers have higher breast cancer risk compared with the general population in all age groups.[ 1 ] BRCA2-negative women with a BRCA2-carrying first-degree relative may also have increased breast cancer risk, a small UK cohort study showed.[ 8 ] Higher sex hormone levels in BRCA mutation carriers may explain some of the increased risk.[ 9 ]

Exposure to non-steroidal anti-inflammatory drugs during pregnancy and risk of miscarriage

exposure to non-steroidal anti-inflammatory drugs during pregnancy and risk of miscarriage

BRCA1 and BRCA2 mutations confer a high risk of breast cancer in carriers (high-penetrance). Women with a BRCA1 or BRCA2 mutation have a 45-65% chance of developing breast cancer by age 70.[ 7 ] BRCA1/2 mutation-carriers have higher breast cancer risk compared with the general population in all age groups.[ 1 ] BRCA2-negative women with a BRCA2-carrying first-degree relative may also have increased breast cancer risk, a small UK cohort study showed.[ 8 ] Higher sex hormone levels in BRCA mutation carriers may explain some of the increased risk.[ 9 ]

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exposure to non-steroidal anti-inflammatory drugs during pregnancy and risk of miscarriageexposure to non-steroidal anti-inflammatory drugs during pregnancy and risk of miscarriageexposure to non-steroidal anti-inflammatory drugs during pregnancy and risk of miscarriageexposure to non-steroidal anti-inflammatory drugs during pregnancy and risk of miscarriageexposure to non-steroidal anti-inflammatory drugs during pregnancy and risk of miscarriage

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