These viruses look identical under the microscope, and either type can infect the mouth or genitals. In the 1960's, the distinction was made that HSV-1 occurs above the waist, and HSV-2 below, but genital HSV-1 infections are increasing.
Herpes Simplex Type 1 (HSV-1) is the virus usually responsible for oral herpes or cold sores. If you receive unprotected oral sex from someone who has (HSV-1) cold sores, you can get genital herpes, or HSV-1 on your genitals.
Herpes Simplex Type 2 (HSV-2) or genital herpes is usually below the waist, but if you perform oral sex on someone who has HSV-2 genital sores, you can get HSV-2 on your face and mouth area.
HSV can also infect other parts of the body. Some other areas could be the eyes and the brain. Herpes Encephalitis is herpes in the brain. Very rare, and only affecting 2 per million, encephalitis is very dangerous and can cause a sore throat, headache, fever, vomitng, coma, and even death if left untreated.
If you have different types and either of you catches a second type, symptoms will probably be slight or non-existent. This is because the antibodies for one type will have some immediate effect on the other type as well. It is called ‘partial protection’.
Antibodies that develop following an initial infection with a type of HSV prevents reinfection with the same virus type—a person with a history of orofacial infection caused by HSV-1 cannot contract herpes whitlow or a genital infection caused by HSV-1. [ citation needed ] In a monogamous couple, a seronegative female runs a greater than 30% per year risk of contracting an HSV infection from a seropositive male partner.  If an oral HSV-1 infection is contracted first, seroconversion will have occurred after 6 weeks to provide protective antibodies against a future genital HSV-1 infection. Herpes simplex is a double-stranded DNA virus .