Non-aromatizable steroids

Dihydrotestosterone (DHT) originates via irreversible reduction of testosterone by catalytic activity of 5alpha-reductase enzyme and it is demonstratively the most effective androgen. Androgens influence adipose tissue in men either directly by stimulation of the androgen receptor or indirectly, after aromatization, by acting at the estrogen receptor. DHT as a non-aromatizable androgen could be responsible for a male type fat distribution. The theory of non-aromatizable androgens as a potential cause of a male type obesity development has been studied intensively. However, physiological levels of DHT inhibit growth of mature adipocytes. In animal models, substitution of DHT in males after gonadectomy has a positive effect on body composition as a testosterone therapy. Thus, DHT within physiological range positively influences body composition. However, there are pathological conditions with an abundance of DHT, . androgenic alopecia and benign prostatic hyperplasia. These diseases are considered as risk factors for development of metabolic syndrome or atherosclerosis. In obese people, DHT metabolism in adipose tissue is altered. Local abundance of non-aromatizable androgen has a negative effect on adipose tissue and it could be involved in pathogenesis of metabolic and cardiovascular diseases. Increased DHT levels, compared to physiological levels, have negative effect on development of cardiovascular diseases. Difference between the effect of physiological and increased level brings about certain paradox.

All anabolic steroids have a tendency to reduce HDL (good) cholesterol and increase LDL (bad) cholesterol. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable) type of steroid (aromatizable or non-aromatizable) and level of resistance to hepatic metabolism. With regards to nandrolone at a dose of 600mg per week over 10 weeks demonstrated 26% reduction in HDL cholesterol levels. This suppression is slightly greater than an equal dose of testosterone over an equal period. In other words it shows a slightly more negative impact on HDL/LDL ratio with nandrolone than with testosterone cypionate. It’s always recommended to accompany the use of this product with a low saturated fat diet and a cardiovascular exercise program.

The first period of prostate growth, deemed developmental growth, is connected to puberty and the testicular secretion of androgens. This takes the prostate from its prepubertal dormancy to the normal sized, healthy, and functional prostate gland of an adult. During the early and mid adult years the prostate stays at this stage, despite the constant levels of high levels of androgens in the body. However, if androgens are blocked in the body then the adult prostate will shrink in size. This can occur by castration, or even by blockade of 5-AR (recall that DHT is the active androgen in the prostate).

It could be argued that aromatization is a non-issue, as an . could always be employed to counter estrogen conversion. This is true, but I believe there is a simpler way to go about it. In my opinion, the ideal pre-contest MPD cycle should consist of a low dose of testosterone propionate (150-200 mg/week), as at least some estrogen is needed to maintain a healthy looking skin tone. This should be combined with 2-3 other anabolics; preferably 1-2 oral anabolics and 1-2 injectables anabolics. Some good examples of orals include: Anavar, Epistane, and Turinabol. As for injectables, most people usually find the following drugs to be compatible: Primo, Boldenone, and Dihydroboldenone (1-testosterone).

Non-aromatizable steroids

non-aromatizable steroids

It could be argued that aromatization is a non-issue, as an . could always be employed to counter estrogen conversion. This is true, but I believe there is a simpler way to go about it. In my opinion, the ideal pre-contest MPD cycle should consist of a low dose of testosterone propionate (150-200 mg/week), as at least some estrogen is needed to maintain a healthy looking skin tone. This should be combined with 2-3 other anabolics; preferably 1-2 oral anabolics and 1-2 injectables anabolics. Some good examples of orals include: Anavar, Epistane, and Turinabol. As for injectables, most people usually find the following drugs to be compatible: Primo, Boldenone, and Dihydroboldenone (1-testosterone).

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