The first internet pharmacy in the UK was Pharmacy2U , which started operating in 1999.  The UK is a frontline leader in internet pharmacy since a change to NHS pharmacy regulations in 2005 that made it legal for pharmacies to fill NHS prescriptions over the internet.  Drugs supplied in this way tend to be medicines which doctors refuse to prescribe for patients, or would charge a private prescription fee, as all patients treated under the National Health Service pay either a flat price or nothing for prescribed medicine (except for medicine classed as lifestyle medicine, . anti-malarials for travel), and medical equipment. [ citation needed ] Since July 2015 the Medicines and Products Regulatory Agency (MHRA) has required online sellers of medicines to adopt an EU wide logo and maintain an entry in the MHRA medicines sellers registry.