Dating back over 1,500 years, one of the earliest recorded uses of marijuana was to numb pain during surgery. They didn’t have microscopes to look at nerve cells back then, but they were already observing something that modern neuroscientists have only explained in the past 20 years. Many of the nerve cells in our body that carry pain signals have cannabinoid receptors , from the body to the spinal cord up into the brain. When researchers activated the cannabinoid receptors in the spinal cords of rats, they would leave their tail on a hot plate for longer before moving it, suggesting that it didn’t hurt as much. One of the brain’s main pathways of pain signals, the periaqueductal gray region, is heavily populated with cannabinoid receptors. Similarly, activating these receptors makes rats less sensitive to pain . Marijuana’s ability to numb pain is one of the reasons some patients seek it to deal with cancer treatment .
A meta-analysis of 34 studies found a reduced risk of mortality from coronary heart disease in men who drank 2 - 4 drinks per day and women who drank 1 - 2 drinks per day.  Alcohol has been found to have anticoagulant properties.   Thrombosis is lower among moderate drinkers than abstainers.  A meta-analysis of randomized trials found that alcohol consumption in moderation decreases serum levels of fibrinogen, a protein that promotes clot formation, while it increases levels of tissue type plasminogen activator, an enzyme that helps dissolve clots.  These changes were estimated to reduce coronary heart disease risk by about 24%. Another meta-analysis in 2011 found favorable changes in HDL cholesterol, adiponectin, and fibrinogen associated with moderate alcohol consumption. 
In estimating the impacts on economic activity and employment from undoing these spending caps, we assume that the composition of discretionary spending is essentially unchanged by shifts in the level of spending. It is theoretically true that cuts to infrastructure spending could be less or more steep than overall spending cuts, but this is nearly impossible to forecast. Further, the discretionary spending cuts currently constituting the policy baseline in the United States (., the budget “sequester”) are across-the-board cuts to every category of discretionary spending, making the assumption that the composition of discretionary spending cuts will be unaffected by the level in fact consistent with current budget law.