Steroid taper adrenal insufficiency


--- Stress is often mentioned by CSS patients around the time of their diagnosis, and in a way this seems related to the adrenal glands as well. A patient in another support group reported reading in "The Stress of Life" by Dr. H. Seyle:.... "the adrenal glands are the processors of stress in our bodies. A person's stress resistance will vary with the competence of his adrenals. Continually stressing them, finally depletes them. When we become exhausted by life, on a mental or physical level, our adrenal glands often fail to keep up, and illness ensues".

Glucocorticoids are potent anti-inflammatories, regardless of the inflammation's cause; their primary anti-inflammatory mechanism is lipocortin-1 (annexin-1) synthesis. Lipocortin-1 both suppresses phospholipase A2 , thereby blocking eicosanoid production, and inhibits various leukocyte inflammatory events ( epithelial adhesion , emigration , chemotaxis , phagocytosis , respiratory burst , etc.). In other words, glucocorticoids not only suppress immune response, but also inhibit the two main products of inflammation, prostaglandins and leukotrienes . They inhibit prostaglandin synthesis at the level of phospholipase A2 as well as at the level of cyclooxygenase /PGE isomerase (COX-1 and COX-2), [29] the latter effect being much like that of NSAIDs , potentiating the anti-inflammatory effect.

Dosing should be individualized based on disease and patient response:

Initial dose: 5 to 60 mg orally per day; may be give once a day or in divided doses
Maintenance dose: Adjust or maintain initial dose until a satisfactory response is obtained; then, gradually in small decrements at appropriate intervals decrease to the lowest dose that maintains an adequate clinical response

Comments :
-Exogenous corticosteroids suppress adrenocorticoid activity the least when given at the time of maximal activity; consider time of maximal adrenal cortex activity (2 AM to 8 AM) when dosing.
-Alternate day therapy may be considered in patients requiring long-term treatment; it may be necessary to return to a full suppressive daily dose in the event of acute flare-ups.

Uses: As an anti-inflammatory or immunosuppressive agent when corticosteroid therapy is appropriate, such as treatment of certain allergic states; nervous system, neoplastic, or renal conditions; endocrine, rheumatologic, or hematologic disorders; collagen, dermatologic, ophthalmic, respiratory, or gastrointestinal diseases; specific infectious diseases or conditions related to organ transplantation.

The discontinuation of prednisone dog treatments should be gradual and performed over several weeks, because if this procedure is not respected, the dog may be affected by hyperadrenocorticism (commonly known as Cushing's disease ) or even adrenal gland insufficiency. This is due to the fact that the cortisone will stimulate the adrenal gland and if the treatment is suddenly discontinued, the adrenal glands may either fail to produce the needed amounts of hormones or produce these hormones in excess. The adrenal glands have to get accustomed to not getting prednisone, by slowly reducing the amounts of prednisone the dog gets.

Steroid taper adrenal insufficiency

steroid taper adrenal insufficiency

The discontinuation of prednisone dog treatments should be gradual and performed over several weeks, because if this procedure is not respected, the dog may be affected by hyperadrenocorticism (commonly known as Cushing's disease ) or even adrenal gland insufficiency. This is due to the fact that the cortisone will stimulate the adrenal gland and if the treatment is suddenly discontinued, the adrenal glands may either fail to produce the needed amounts of hormones or produce these hormones in excess. The adrenal glands have to get accustomed to not getting prednisone, by slowly reducing the amounts of prednisone the dog gets.

Media:

steroid taper adrenal insufficiencysteroid taper adrenal insufficiencysteroid taper adrenal insufficiencysteroid taper adrenal insufficiencysteroid taper adrenal insufficiency

http://buy-steroids.org